Caryophyllene is the only terpene that is able to act as a cannabinoid by directly binding to endocannabinoid receptors. Particularly CB2 receptors primarily located within our peripheral nervous system. It's one of the most abundant terpenes found in cannabis and offers a pungent, spicy aroma. It's is also found in Basil, Oregano, Rosemary, Black Caraway, and Cinnamon.
Because of Caryophyllene's ability to bind to CB2 receptors rather than CB1 receptors, it doesn't provide any of the psychoactive affects commonly associated with cannabis. CB2 receptors are associated with modulation of neuropathic type pain and inflammation.
Consuming Caryophyllene through black peppercorns while experiencing THC induced paranoia has been a long-time weed hack used by cannabis enthusiasts for decades. Again Caryophyllenes ability to bind with CB2 receptors help balance out the affects of the cannabinoid THC, offering a soothing therapeutic sensation.